SOLID project
Effects of early-Stress On Lipid mediators and Inflammation for early Detection of neurodegeneration (SOLID)
The Joint Research Program incorporates seven main partners in a large-scale project with total funding of approximately $CA 2 million from the European Union's Joint Research Program on Neurodegenerative Diseases (JPND). The project, which stems from the Food4BrainHealth International Research Network and the International Associated Laboratory Optinutribrain, brings together the expertise of researchers from France, Australia, the Netherlands, Hungary, Germany and Canada.
Early life stress and new biomarkers
This ambitious project will shed light on the effects of exposure to several risk factors early and later in life on lipid and inflammatory mediators, with a view to early detection of Alzheimer's disease. Through this international collaborative project, new biomarkers of cognitive decline, the impact of polyunsaturated fatty acids (omega-6 and omega-3) and their mechanisms in the brain will be studied, ultimately leading to the development of intervention strategies.
A BRIEF VIEW OF THE PROJECT
Risk factors and markers for early detection of Alzheimer’s Disease: focus on early-life stress, inflammation and lipid mediators
Duration: 36 months
Total funding: 1, 635, 428 euros
Main partners
- Australia : Prof. Sarah J. Spencer, RMIT University
- The Netherlands : Prof. Aniko Korosi, University of Amsterdam
- Australia : Dr Luba Sominsky Barwon Health
- France : Prof. Sophie Layé, NutriNeuro, Inrae, Université de Bordeaux
- Germany : Prof. Christoph Rummel, Justus Liebig University
- Canada : Prof. Frédéric Calon, INAF, Université Laval
- Hungary : Prof. Peter, Budapest University of technology and Economics
External collaborators and student
See table below
About the JPND program
The European Union's Joint Program for Neurodegenerative Disease Research (JPND) is the world's largest research initiative to address the challenge of neurodegenerative diseases. JPND aims to increase coordinated investment among participating countries in research to find the causes, develop cures, and identify appropriate ways to care for people with neurodegenerative diseases.
Name | Affiliations | |
MAIN PARTNERS | ||
Sarah J. Spencer | RMIT University, Australia | sarah.spencer@rmit.edu.au |
Frédéric Calon | Université Laval, Canada | Frederic.Calon@pha.ulaval.ca |
Christoph Rummel | Justus Liebig University Giessen, Germany | Christoph.D.Rummel@vetmed.uni-giessen.de |
Sophie Layé Jean-Christophe Delpech | Université de Bordeaux, France | |
Aniko Korosi | University of Amsterdam, the Netherlands | A.Korosi@uva.nl |
Peter Antal | Budapest University of Technology and Economics, Hungary | antal@mit.bme.hu |
Luba Sominsky | Barwon Health, Deakin University, Australia | luba.sominsky@deakin.edu.au |
COLLABORATORS | ||
Richard Bazinet | University of Toronto, Canada | richard.bazinet@utoronto.ca |
Anne-Louise Ponsonby | The Florey Institute, MCRI, University of Melbourne, Australia | annelouise.ponsonby@florey.edu.au |
Suzanne R. de Rooji | Amsterdam UMC, University of Amsterdam, the Netherlands | |
Jean-Christophe Delpech | Université de Bordeaux, France | jean-christophe.delpech@inrae.fr |
Carsten Culmsee | Philipps-Universität Marburg Institute for Pharmacology and Clinical Pharmacy, Germany | culmsee@staff.uni-marburg.de |
Bart Eggen | University Medical Center Groningen, the Netherlands | b.j.l.eggen@umcg.nl |
Peter Vuillermin | Barwon Health and Deakin University, Australia | peter.vuillermin@deakin.edu.au |
STUDENTS | ||
Martin Feldotto | Institut für Veterinär-Physiologie und -Biochemie Justus-Liebig-Universität, Allemagne | Martin.Feldotto@vetmed.uni-giessen.de |
Pasindu Singhaarachchi | RMIT University (Sarah Spencer) | s3714630@student.rmit.edu.au |
Publications
Norepinephrine Inhibits Lipopolysaccharide-Stimulated TNF-α but Not Oxylipin Induction in n-3/n-6 PUFA-Enriched Cultures of Circumventricular Organs, Int. J. Mol. Sci. 2022, 23(15), 8745; https://doi.org/10.3390/ijms23158745 |